CIA agents and best friends Franklin "FDR" Foster (Chris Pine) and Tuck Hansen (Tom Hardy) are deployed to Hong Kong to prevent international criminal Karl Heinrich (Til Schweiger) from acquiring a weapon of mass destruction, but the mission goes awry, resulting in the death of Heinrich's brother, Jonas. Heinrich swears vengeance against them. Upon returning to America, their boss, Collins (Angela Bassett) assigns them to desk duty for their protection.