After his latest creation accidentally destroys the city center and then shoots up into the sky, Flint Lockwood initially fears that his career as an inventor is over. But then the unbelievable happens: It rains delicious cheeseburgers - his machine works! But people just can't get enough of the tasty treats until the machine goes haywire and unleashes gigantic spaghetti tornadoes with huge meatballs onto the earth. With the help of weather reporter Sam Sparks and his assistant Steve, a talking monkey, Flint must find a way to shut down the runaway machine before the world is buried under the mega-sized meatballs.