The film follows the adventures of El Superbeasto (Tom Papa), a suave, yet violent exploitation film actor/director and former masked wrestler, and his sultry "sidekick" and sister, the super-agent Suzi-X (Sheri Moon Zombie), as they prevent the evil Dr. Satan (Paul Giamatti) from taking over the world by marrying the foul-mouthed stripper with the mark of the devil on her backside, Velvet Von Black (Rosario Dawson) . The adventure, set in the mythic world of Monsterland, also features Murray the Robot (Brian Posehn), Suzi-X's sidekick and vehicle, based on the robot featured in the 1939 serial ''The Phantom Creeps'' starring Bela Lugosi.