The film centers around a serial killer known as "The Card Player", who is kidnapping young women in Rome. Using a webcam set-up, the killer challenges the police by forcing them to play hands of Internet poker. If the police lose, the kidnapped victim is tortured and murdered on-screen. When a British tourist is among the girls murdered, policeman John Brennan (Cunningham) is assigned the case and quickly teams up with Italian detective Anna Mari (Rocca). The duo have their work cut out for them when the Police Chief's daughter (Argento) becomes the killer's latest kidnapping victim.