By the year 2056, an epidemic of organ failures has devastated the planet. The megacorporation GeneCo provides organ transplants on a payment plan. Clients who default on payments are hunted down by Repo Men: skilled assassins contracted by GeneCo to repossess organs, usually killing the clients in the process. The CEO of GeneCo, Rottissimo "Rotti" Largo (as listed in a newspaper article about his kids), discovers he is terminally ill. Rotti's three children, Luigi Largo, Pavi Largo, and Amber Sweet (Carmela Largo), who changed her name to help her become a popular singer, bicker over who will inherit GeneCo. Rotti believes none of his children are worthy heirs, as they consistently embarrass him with their robust attitudes, and instead plans to pass on his fortune to Shilo, the daughter of his ex-fiancé Marni.