The film tells the story of Sissy Hankshaw, a woman born with a mutation (she would not call it a birth defect) giving her enormously large thumbs. The film is a transgressive romp, covering topics from homosexuality and free love to drug use and political rebellion to animal rights and body odor and religions. Sissy makes the most of her thumbs by becoming a hitchhiker. Her travels eventually take her to New York, where she becomes a model for a homosexual feminine hygiene products mogul, known as The Countess, a few years later, he introduces her to his "beauty ranch" the Rubber Rose Ranch. The main plot revolves around the cowgirls who work at the ranch after they violently take over and drug the endangered whooping cranes who nest along the lake on their land making the once migratory birds stay. The cowgirls end up in a showdown with government agencies because the cranes won't leave the ranch and the cowgirls refuse to allow the men on the ranch to take the cranes. Sissy and the ranch leader, Bonanza Jellybean have a brief love affair. After a fatal shootout between the cowgirls and the various agencies, the cranes leave, and Sissy takes over running the ranch.