In Chicago's Southside, as the effects are narrated by Dolemedes, a war rages between two rival gangs: the Spartans, led by rapper/gang leader Demetrius Dupree, nicknamed "Chi-Raq" and the Trojans, led by gang lord Cyclops. Demetrius's lover, Lysistrata, grows disillusioned after several outbursts of violence near her, including a shootout at Demetrius's concert, an arson attack at their home while the two are having sex and a young girl, Patti, being accidentally killed in a gang shooting, revealed as the daughter of Irene. Lysistrata moves in after the fire with Miss Helen Worthy, a well-read non-violence advocate who suggests she research about Leymah Gbowee, who led a peace movement to stop the Second Liberian Civil War and threatened a sex strike. Inspired by Worthy and Gbowee, Lysistrata organizes a meeting between herself, the Spartans' lovers and the Trojans' lovers, where they agree to Sex strike until the men agree to lay down arms, hence their plea, "No Peace, No Pussy."