''Vincent & Theo'' has a prelude, which is documentary footage of the 1987 auction of one of Vincent van Gogh's paintings at Christie's, a famed London art business. The painting sells for millions of pounds. The film then cuts to scenes that take place in the period from 1883 through 1891, commencing with Vincent van Gogh's decision to work exclusively as an artist, and concluding with his death and that of his brother Theo a few months later. The film is a double portrait of both men; Noel Murray has summarised this aspect, "Altman and screenwriter Julian Mitchell contrast Theo's life—which mostly consists of him guiding rich people through galleries and selling them paintings he despises—with Vincent's gradual development of his own voice and style, through hard physical labor. ''Vincent & Theo'' also shows both men as warped by a similar madness, torn between their lusts for sex and alcohol, and their yearnings for social respectability and religious connection."<ref name=Murray></ref>