The F+B Ambulance Company is locked in an intense battle with the Unity Ambulance Company to win a city contract for providing ambulance service to a territory within Los Angeles. Their star driver is "Mother" Tucker (Bill Cosby), a talented antihero who drinks alcohol on duty, harasses nuns, and behaves brazenly towards practically everybody he meets, including his partner Leroy (Bruce Davison). Indeed, the entire company is a band of misfits, including the hypersexual John Murdoch (Larry Hagman), his partner Walker (Michael McManus (American actor)), putative medical student Bliss (Allan Warnick), and brash Texan "Rodeo" Moxey (Dick Butkus). Handling calls at the Telephone switchboard is Jennifer (Raquel Welch), whom the drivers nickname "Jugs" for her Breast. Harry "Doughnut" Fishbine (Allen Garfield) runs the company, using occasionally underhanded means (such as briberys) to maintain an income stream.