''Mi Vida Loca'' tells the story of young Mexican-American women in Los Angeles and the struggles they have in a life of poverty and early motherhood while being members of an infamous street gang. Mousie (Seidy López) and Sad Girl (Angel Aviles) are best friends from childhood, growing up in Echo Park, Los Angeles, California, a neighborhood that had a significant amount of gang activity in the late 1980s and early 1990s era. They pride themselves for remaining loyal to each other and their gang. But when Sad Girl sleeps with Mousie's boyfriend (a member of their neighborhood gang who is killed in a drug deal gone bad) and becomes pregnant, their friendship is ruptured.