At the small-town fictional New England college campus of Braylin, philosophy professor Abe Lucas (Joaquin Phoenix) is experiencing an existential crisis. He is depressed, sees no meaning in his life, and drinks excessively. Despite this, he immediately catches the eye of two women: chemistry professor Rita Richards (Parker Posey), and Jill Pollard (Emma Stone), one of his students. Jill has a serious boyfriend and lives with her parents. Rita lives with her husband, but is dissatisfied with her marriage. Abe chooses to sleep with Rita but is careful to have only a platonic relationship with Jill. Abe's depression becomes even more apparent when he fails to have an erection during his first sexual experience with Rita.