In Manhattan in the early 1990s, Frank Pierce is a burned-out Voluntary ambulance (New York City) who works the graveyard shift in a two-man ambulance team with various different partners. Usually exhausted and depressed, he has not saved any patients in months and begins to see the ghosts of those lost, especially a homeless adolescent girl named Rose whose face appears on the bodies of others. Frank and his first partner Larry respond to a call by the family of a man named Mr. Burke who has entered cardiac arrest. Frank befriends Mr. Burke's distraught daughter Mary, a former junkie. Frank discovers Mary was childhood friends with Noel, a brain-damaged drug addict and delinquent who is frequently sent to the hospital.